Papers from our users

Sep 21, 2023


Event Description

Li S, Mereby SA, Rothstein M, Johnson MR, Brack BJ, Mallarino R. TIGER: Single-step in vivo genome editing in a non-traditional rodent. Cell Rep. 2023 Aug 29;42(8):112980. doi: 10.1016/j.celrep.2023.112980. Epub 2023 Aug 11. PMID: 37573509.

Verpeut JL, Bergeler S, Kislin M, William Townes F, Klibaite U, Dhanerawala ZM, Hoag A, Janarthanan S, Jung C, Lee J, Pisano TJ, Seagraves KM, Shaevitz JW, Wang SS. Cerebellar contributions to a brainwide network for flexible behavior in mice. Commun Biol. 2023 Jun 5;6(1):605. doi: 10.1038/s42003-023-04920-0. PMID: 37277453; PMCID: PMC10241932.

Maturana CJ, Chan A, Verpeut JL, Engel EA. Local and systemic administration of AAV vectors with alphaherpesvirus latency-associated promoter 2 drives potent transgene expression in mouse liver, kidney, and skeletal muscle. J Virol Methods. 2023 Apr;314:114688. doi: 10.1016/j.jviromet.2023.114688. Epub 2023 Feb 1. PMID: 36736702; PMCID: PMC10236909.

Cox J, Minerva AR, Fleming WT, Zimmerman CA, Hayes C, Zorowitz S, Bandi A, Ornelas S, McMannon B, Parker NF, Witten IB. A neural substrate of sex-dependent modulation of motivation. Nat Neurosci. 2023 Feb;26(2):274-284. doi: 10.1038/s41593-022-01229-9. Epub 2023 Jan 16. PMID: 36646878.

Diethorn EJ, Gould E. Postnatal development of hippocampal CA2 structure and function during the emergence of social recognition of peers. Hippocampus. 2023 Mar;33(3):208-222. doi: 10.1002/hipo.23476. Epub 2022 Oct 30. PMID: 36309963; PMCID: PMC10028396.

Willmore L, Cameron C, Yang J, Witten IB, Falkner AL. Behavioural and dopaminergic signatures of resilience. Nature. 2022 Nov;611(7934):124-132. doi: 10.1038/s41586-022-05328-2. Epub 2022 Oct 19. PMID: 36261520

Chan A, Maturana CJ, Engel EA. Optimized formulation buffer preserves adeno-associated virus-9 infectivity after 4 °C storage and freeze/thawing cycling. J Virol Methods. 2022 Nov;309:114598. doi: 10.1016/j.jviromet.2022.114598. Epub 2022 Aug 5. PMID: 35940276.

Fleming W, Lee J, Briones BA, Bolkan SS, Witten IB. Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes. Cell Rep. 2022 May 31;39(9):110874. doi: 10.1016/j.celrep.2022.110874. PMID: 35649378; PMCID: PMC9196889.

Parker NF, Baidya A, Cox J, Haetzel LM, Zhukovskaya A, Murugan M, Engelhard B, Goldman MS, Witten IB. Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning. Cell Rep. 2022 May 17;39(7):110756. doi: 10.1016/j.celrep.2022.110756. PMID: 35584665; PMCID: PMC9218875.

Bolkan SS, Stone IR, Pinto L, Ashwood ZC, Iravedra Garcia JM, Herman AL, Singh P, Bandi A, Cox J, Zimmerman CA, Cho JR, Engelhard B, Pillow JW, Witten IB. Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state. Nat Neurosci. 2022 Mar;25(3):345-357. doi: 10.1038/s41593-022-01021-9. Epub 2022 Mar 7. PMID: 35260863; PMCID: PMC8915388.

Pisano TJ, Hoag AT, Dhanerawala ZM, Guariglia SR, Jung C, Boele HJ, Seagraves KM, Verpeut JL, Wang SS. Automated high-throughput mouse transsynaptic viral tracing using iDISCO+ tissue clearing, light-sheet microscopy, and BrainPipe. STAR Protoc. 2022 Apr 14;3(2):101289. doi: 10.1016/j.xpro.2022.101289. PMID: 35496792; PMCID: PMC9038781.

Tara A. Fortino, Margo L. Randelman, Adam A. Hall, Jasbir Singh, David C. Bloom, Esteban Engel, Daniel J. Hoh, Shaoping Hou, Lyandysha V. Zholudeva, Michael A. Lane, Transneuronal tracing to map connectivity in injured and transplanted spinal networks, Experimental Neurology 2022.

Christos M. Suriano, Jessica L. Verpeut, Neerav Kumar, Jie Ma, Caroline Jung, Lisa M. Boulanger. Adeno-associated virus (AAV) reduces cortical dendritic complexity in a TLR9-dependent manner. bioRxiv 2021.09.28.462148; doi:

Cope EC, Zych AD, Katchur NJ, Waters RC, Laham BJ, Diethorn EJ, Park CY, Meara WR, Gould E. Atypical perineuronal nets in the CA2 region interfere with social memory in a mouse model of social dysfunction. Mol Psychiatry. 2022 Aug;27(8):3520-3531. doi: 10.1038/s41380-021-01174-2. Epub 2021 Jun 28. Erratum in: Mol Psychiatry. 2022 Apr 22;: PMID: 34183768; PMCID: PMC8712624.

Thomas J. Pisano, Zahra M. Dhanerawala, Mikhail Kislin, Dariya Bakshinskaya, Esteban A. Engel, Ethan J. Hansen, Austin T. Hoag, Junuk Lee, Nina L. de Oude, Kannan Umadevi Venkataraju, Jessica L. Verpeut, Freek E. Hoebeek, Ben D. Richardson, Henk-Jan Boele, Samuel S.-H. Wang. Homologous organization of cerebellar pathways to sensory, motor, and associative forebrain. CELL REPORTS 2021.

Maturana, C.J., Verpeut, J.L., Kooshkbaghi, M, Engel, E. A. Novel tool to quantify with single-cell resolution the number of incoming AAV genomes co-expressed in the mouse nervous system. GENE THERAPY 2021

Duan CA, Pagan M, Piet AT, Kopec CD, Akrami A, Riordan AJ, Erlich JC, Brody CD. Collicular circuits for flexible sensorimotor routing. NATURE NEUROSCIENCE 2021

Fleming W, Jewell S, Engelhard B, Witten DM, Witten IB. Inferring spikes from calcium imaging in dopamine neurons. PLOS ONE 2021

Renner DW, Parsons L, Shreve JT, Engel EA, Kuny CV, Enquist L, Neumann D, Mangold C, Szpara ML. Genome Sequence of the Virulent Model Herpes Simplex Virus 1 Strain McKrae Demonstrates the Presence of at Least Two Widely Used Variant Strains. MICROBIOLOGY RESEARCH ANNOUNCEMENT 2021 Mar 25;10(12):e01146-19. doi: 10.1128/MRA.01146-19. PMID: 33766904; PMCID: PMC7996463.


McEwan S, Kwon H, Tahiri A, Shanmugarajah N, Cai W, Ke J, Huang T, Belton A, Singh B, Wang L, Pang Z, Dirice E, Engel EA, El Ouaamari A. Deconstructing the origins of sexual dimorphism in sensory modulation of pancreatic β cells.ular Metabolism. MOLECULAR METABOLISM 2021. PMID: 34023484 DOI: 10.1016/j.molmet.2021.101260


Jolien Van Cleemput, Orkide O. Koyuncu, Kathlyn Laval, Esteban A. Engel, Lynn W. Enquist. CRISPR/Cas9-constructed pseudorabies virus mutants reveal the importance of UL13 in alphaherpesvirus escape from genome silencing. Journal of Virology 2021 February 95 (6), JVI.02286-20;


Briones, BA, Pisano, TJ, Pitcher, MN, Haye AE, Diethorn EJ, Engel EA, Cameron HA, Gould E. Adult‐born granule cell mossy fibers preferentially target parvalbumin‐positive interneurons surrounded by perineuronal nets. Hippocampus. 2021; 31(4) 375-88.

Jung Yoon Choi, Hee Jae Jang, Sharon Ornelas, Weston T. Fleming, Daniel Furth, Jennifer Au, Akhil Bandi, Esteban A. Engel, and Ilana B. Witten. A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory. CELL REPORTS. 2020 December 15, 33(11).

Lili X. Cai, Katherine Pizano, Gregory W. Gundersen, Cameron L. Hayes, Weston T. Fleming, Sebastian Holt, Julia M. Cox, Ilana B. Witten. Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times. ELIFE. 2020 June 10.

Carola J. Maturana, Jessica L Verpeut, Thomas J Pisano, Zahra M Dhanerawala, Andrew Esteves, Lynn W Enquist, Esteban A Engel. Small Alphaherpesvirus Latency-Associated Promoters Drive Efficient and Long-Term Transgene Expression in CNS. MOLECULAR THERAPY. 2020 June 12 (17) 843-857.

Constantinople CM, Piet AT, Bibawi P, Akrami A, Kopec C, Brody CD. Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases. ELIFE. 2019 Nov 6;8:e49744. doi: 10.7554/eLife.49744. PMID: 31692447; PMCID: PMC6834367.

Alexander R. Nectow, Marc Schneeberger, Luca Parolari, Tania Das Banerjee, Varun Bhave, Putianqi Wang, Bindiben Patel, Thomas Topilko, Zhuhao Wu, Chan Hee J. Choi, Xiaofei Yu, Kyle Pellegrino, Esteban A. Engel, Paul Cohen, Nicolas Renier, Jeffrey M. Friedman. Regulation of Energy Expenditure by Brainstem GABA Neurons. CELL. 2019 June 25.

Akrami A, Kopec CD, Diamond ME, Brody CD. Posterior parietal cortex represents sensory history and mediates its effects on behaviour. NATURE 2018 Feb 15;554(7692):368-372.

Murugan M, Jang HJ, Park M, Miller EM, Cox J, Taliaferro JP, Parker NF, Bhave V, Hur H, Liang Y, Nectow AR, Pillow JW, Witten IB. Combined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex. CELL. 2017 Dec14;171(7):1663-1677.e16.

Badura A, Verpeut JL, Metzger JW, Pereira TD, Pisano TJ, Deverett B, Bakshinskaya DE, Wang SS. Normal cognitive and social development require posterior cerebellar activity. ELIFE. 2018 Sep 20;7. pii: e36401. doi:10.7554/eLife.36401.

Cameron CM, Murugan M, Choi JY, Engel EA, Witten IB. Increased Cocaine Motivation Is Associated with Degraded Spatial and Temporal Representations in IL-NAc Neurons. NEURON. 2019 May 2. pii: S0896-6273(19)30350-2. doi:10.1016/j.neuron.2019.04.015.  

Engelhard B, Finkelstein J, Cox J, Fleming W, Jang HJ, Ornelas S, Koay SA, Thiberge SY, Daw ND, Tank DW, Witten IB. Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons. NATURE. 2019 May 29. doi: 10.1038/s41586-019-1261-9.